2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W585809R
    1,3-Distearoyl-2-chloropropanediol (Standard) 26787-56-4
    1,3-Distearoyl-2-chloropropanediol (Standard) is the analytical standard of 1,3-Distearoyl-2-chloropropanediol. This product is intended for research and analytical applications. 1,3-Distearoyl-2-chloropropanediol (2-Chloropropane-1,3-diyl distearate) is an ester product.
    1,3-Distearoyl-2-chloropropanediol (Standard)
  • HY-W585827R
    2-Chloro-1,3-propanediol (Standard) 497-04-1
    2-Chloro-1,3-propanediol (Standard) is the analytical standard of 2-Chloro-1,3-propanediol. This product is intended for research and analytical applications. 2-Chloro-1,3-propanediol is an ester product.
    2-Chloro-1,3-propanediol (Standard)
  • HY-W587803R
    Propionylglycine (Standard) 21709-90-0
    Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.
    Propionylglycine (Standard)
  • HY-W658339A
    Methyl threo-9,10-dihydroxyoctadecanoate 3639-31-4
    Methyl threo-9,10-dihydroxyoctadecanoate is an ester product.
    Methyl threo-9,10-dihydroxyoctadecanoate
  • HY-W724781A
    Methyl cis-9,10-methylenehexadecanoate 36254-90-7
    Methyl cis-9,10-methylenehexadecanoate is an ester product.
    Methyl cis-9,10-methylenehexadecanoate
  • HY-W777866A
    3-Chloro-2-(stearoyloxy)propyl (9Z,12Z)-octadeca-9,12-dienoate 1336935-07-9
    3-Chloro-2-(stearoyloxy)propyl (9Z,12Z)-octadeca-9,12-dienoate is an ester product.
    3-Chloro-2-(stearoyloxy)propyl (9Z,12Z)-octadeca-9,12-dienoate
  • HY-W782236A
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid 503-07-1
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid is an ester product.
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid
  • HY-W008614S1
    Lansoprazole sulfone-13C6 1261398-50-8
    Lansoprazole sulfone-13C6 (AG-1813-13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
    Lansoprazole sulfone-13C6
  • HY-W009204S5
    Fmoc-Ala-OH-13C3 765259-05-0
    Fmoc-Ala-OH-13C3 is a 13C-labeled Fmoc-Ala-OH (HY-W009204). Fmoc-Ala-OH is an alanine derivative.
    Fmoc-Ala-OH-13C3
  • HY-W010031S1
    1-Methyluric acid-d3 1189480-64-5
    1-Methyluric acid-d3 is the deuterium labeled 1-Methyluric acid (HY-W010031). 1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.
    1-Methyluric acid-d3
  • HY-W010450S5
    Thymine-13C5,15N2 2483830-13-1
    Thymine-13C5,15N2 (5-Methyluacil-13C5,15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-13C5,15N2
  • HY-W010476S1
    2,3,5-Trimethylpyrazine-d3 1082582-30-6
    2,3,5-Trimethylpyrazine-d3 is deuterated labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d3
  • HY-W010489S1
    2-Phenylacetaldehyde-13C2 1083053-39-7
    2-Phenylacetaldehyde-13C2 is 13C labeled 2-Phenylacetaldehyde (HY-W010489). 2-Phenylacetaldehyde is an endogenous metabolite.
    2-Phenylacetaldehyde-13C2
  • HY-W010489S2
    2-Phenylacetaldehyde-d5 879549-73-2
    2-Phenylacetaldehyde-d5 is deuterated labeled 2-Phenylacetaldehyde (HY-W010489). 2-Phenylacetaldehyde is an endogenous metabolite.
    2-Phenylacetaldehyde-d5
  • HY-W011297S2
    Methyl arachidonate-13C4 2692624-39-6
    Methyl arachidonate-13C4 (Arachidonic acid methyl ester-13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C4
  • HY-W011297S3
    Methyl arachidonate-13C5
    Methyl arachidonate-13C5 (Arachidonic acid methyl ester-13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C5
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-15N5
  • HY-W012241S1
    Dodecanedioic acid-d4 97543-02-7 99.95%
    Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid-d4
  • HY-W013049S2
    Docosanoic acid-d2 71607-34-6
    Docosanoic acid-d2 (Behenic acid-d2) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
    Docosanoic acid-d2
  • HY-W014423S1
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate 2483829-32-7
    L-Histidine-13C6,15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate
Cat. No. Product Name / Synonyms Application Reactivity